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Allergens or toxins in the urine are thought to cause the bladder walls to become sensitized to increased mast cells.[ref][ref][ref] Vulvodynia and mast cell activation: Vulvodynia is a chronic genital pain condition that includes an increased number of mast cells

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This is the most expensive route but offers the highest quality assurance and medical oversight

While there's no upper limit to how much vitamin B12 you can take, there are general dosage recommendations

10.1016/j.jhep.2019.06.018 122 ShaoT.ZhaoC.LiF.GuZ.LiuL.ZhangL.et al (2018)