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To relax the log(linear) assumption usually applied to continuous doseresponse risk and make the estimates robust to the placement of spline knots, we used an ensemble spline approach to fit the functional form of the doseresponse relationship

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The utility of studies using whole-body exposures in animal models when examining health effects of e-cigarette aerosols is limited because this type of exposure may overestimate or underestimate an exposure in the human condition

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