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Collagen and Extracellular Matrix Remodeling GHK-Cu activates fibroblasts, increasing the synthesis of: Type I and III collagen Elastin Proteoglycans Glycosaminoglycans (including hyaluronic acid) This mechanism helps restore structural integrity, improving firmness, elasticity, and volume over time

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Specifically, total RNA was extracted from LCLs at baseline using the RNeasy kit (Qiagen, Valencia, CA)

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