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Hyperglycemia acutely lowers the postprandial excursions of glucagon-like peptide-1 and gastric inhibitory polypeptide in humans

When we applied the same methods used in the GLP-1 analysis, these drugs showed no difference in fracture risk between the exposure and non-exposed patients

However, iNOS can control arginase activity by generating hydroxy-L-arginine, an intermediate in NO synthesis, to inhibit arginase activity

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Understanding these risks enables informed decision-making and appropriate monitoring during treatment