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On April 28, 2026, the FDA announced two successful proof-of-concept real-time trials in which sponsors report endpoints and data signals to the agency as they occur, instead of collecting, analyzing, and submitting data in batches

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By binding to GLP-1 receptors in the hypothalamus, they reduce appetite and promote satiety, leading to significant weight reduction in clinical trialswith newer agents achieving approximately 15% weight loss in obesity without diabetes (semaglutide) and up to 21% (tirzepatide), with somewhat lower reductions typically seen in patients with type 2 diabetes