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In: Martin CR, Preedy VR, Patel VB, Rajendram R (eds) Handbook of the biology and pathology of mental disorders

Garro, A

This claim requires significant caution, as long-term human data is not available to confirm durability of results

PPI safety for long-term use Extended PPI use (longer than 8 weeks at full dose) carries potential risks including magnesium depletion, B12 deficiency, slightly increased fracture risk, and possible kidney effects

Meanwhile, alcohol can lead to nausea (as many people have experienced when they drink too much) because of acetaldehyde, a by-product that's produced when your body processes alcohol