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Other GPCR targeted for the regulation of energy homeostasis 5-hydroxytryptamine receptor 2C (5-HT2CR) Rodent studies have demonstrated that 5-HT2CR mediates most of the food intake and body weight effects of d-fenfluramine and sibutramine, but it was withdrawn from clinical use due to increased heart rate and blood pressure (117)

For the immunostaining of cultured PSCs, cells were fixed in 4% PFA for 15 min followed by a 15-min incubation in 0.5% Triton-X100

Obesity (Silver Spring) 25(2):311316 Iacobellis G, Villasante Fricke AC (2020) Effects of semaglutide versus dulaglutide on epicardial fat thickness in subjects with type 2 diabetes and obesity