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doi:10.1007/s11684-021-0871-4 Alomari MA, Khabour OF, Gharaibeh MY, Qhatan RA

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11 Although low concentrations of PPA may be beneficial, humans with impairments in PPA metabolism (that is, propionic or methymalonic acidemia, holocarboxylase, biotinidase or B12 deficiency, valproate or ethanol exposure) exhibit neurodevelopmental conditions with behavioral and biochemical similarities to ASD