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IGF-1 LR3 and PEG-MGF are listed on the World Anti-Doping Agency (WADA) Prohibited List under category S2 (peptide hormones, growth factors, and related substances), making them prohibited year-round for athletes subject to anti-doping testing

It has been noted to promote muscle fiber growth, activate satellite cells, and increase tissue repair in preclinical studies

It is hypothesized that these differences might stem from IGF-1 LR3's diminished propensity to form complexes with IGFBPs, which might influence its bioavailability and interaction with target tissues in experimental models

In summary, dysbiosis might contribute to neurodegeneration by disrupting metabolic homeostasis reducing beneficial metabolites (SCFAs, vitamins) and increasing potentially neurotoxic ones (e.g