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Deletion of Glu155 causes a deficiency of glutathione transferase omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs

SVV 3 C pro targeted GPX4 axis for degradation SVV 3C pro triggers pyroptosis through the cleavage of gasdermin D (GSDMD) and causes host cell apoptosis via the cleavage of poly (ADP-ribose) polymerase (PARP) [16, 42, 43]

The GPOX activity of VA13 was increased by 9% and 23% at MDS and SDS conditions, whereas GPOX activity of VA15 was increased by 18% and 29% at MDS and SDS conditions, respectively in comparison with control treatment

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As mitochondria are a central hub for energy production in neurons, they are particularly vulnerable to oxidative damage