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2) the gut microbiota might be not only the pharmacological target, but also the main site of metabolism, resulting in a low oral bioavailability

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Journal of Investigative Dermatology 117(6):1350-1356. [doi.org]

These mice were then randomly divided into eight groups (seven mice per group): a vehicle group, an MXD (MXD) group, an imidocarb (1%) group, a profavine (1%) group, an abemaciclib (1%) group, an aminoacridine (1.0%) group, an aminoacridine (0.3%) + MXD (0.3%) group, and an aminoacridine (1.0%) + MXD (0.3%) group

With a background in neuroscience from UCLA, an M.D