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In monotherapy, the most promising results were observed with the administration of 40 M fisetin, leading to a reduction in the viability of cancer cells to approximately 50% compared to the control group and the induction of apoptosis in about 20% of the cells [139]

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Future directions should prioritize single-cell multi-omics, immune-tumor co-modeling, and real-time clinical feedback systems to unlock the full potential of organoid-informed metabolic therapy in CRC

Chemically, vitamin B12 can exist in various forms