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The Ecuadorian Laron and Brazilian Itabaianinha cohorts with congenital mutations in the GH and GHRH receptors, respectively, both provide a unique and arguably the purest examples to evaluate the effects of chronic severe IGF-I and both severe GH and IGF-I deficiency, respectively, with severe hypoinsulinemia being the common denominator in both cohorts (151, 152) ( Table 1

Saunders 2003 Der Glucagonrezeptor gehrt in die Gruppe der heptahelikalen Rezeptormolekle

101 , 15651573.e18 (2014)

[DOI: 10.2337/dc21-0727]Novo Nordisk