Finally, Long-term toxicology remains incomplete
coeliac) Infections & surgical interventions Pregnancy & neonates Pharmaceutical interactions Nitrous oxide abuse Age greater than 65 years Signs and symptoms of B12 deficiency Anaemia (weakness, tiredness, dyspnoea on exertion) Gastrointestinal (loss of appetite, sore tongue and mouth, epigastric discomfort, nausea, vomiting, heartburn) Neurological (numbness, pins and needles, impaired fine finger movements) Developmental delay in infants Positive Rombergs sign Impaired vibration or position sense, impaired vision Orthostatic dizziness Loss of taste or smell Psychological & psychiatric disturbance When to test for B12 deficiency If a patient has at least 1 risk factor and 1 or more signs, then B12 assessment is warranted
However, there is lack of awareness in India regarding the food source of Vit B12
Unlike oral supplements, an injection delivers vitamin B12 directly into the body without relying on digestive absorption which can be reduced by age, certain medications such as proton pump inhibitors or metformin, or gastrointestinal conditions
Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice
