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and MIMS-iron, with pro-inflammatory molecular features, including increased expression of MHC class II, ferritin complex, FcY receptor for immunoglobulin, and complement C1 complex (C1QA and C1QB) expressing genes for ribosomal proteins, indicating a role in antigen presentation and perpetuation of inflammation (108)

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In contrast, modern humans developed unique lifestyles and technologies that enabled an unprecedented extension of lifespan (Figure 2)