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[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Remington R., Lortie J.J., Hoffmann H., Page R., Morrell C., Shea T.B

It is broken down by different enzymes and when the enzymes are not present or you may be suffering from an issue that makes it difficult to break down histamine, then histamine levels will build up and create a cascade of symptoms

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What it does not yet represent is a proven, approved therapy for longevity or metabolic disease