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L-Arginine: Improves blood flow to deliver immune cells where needed

with acetic acid Flow rate: 1.0 mL/min Injection volume: 100 L Detection Fluorescence, 338 nm excitation, 458 nm emission Note Author Michaelsen, J

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In summary, the plasticity of macrophages in ALD, particularly their ability to switch between M1 and M2 phenotypes, plays a crucial role in both liver injury and repair.32 While M1 macrophages drive the inflammatory response during alcohol-induced liver damage,32 M2 macrophages facilitate tissue healing and inflammation resolution.45 Disruptions in this balance, as seen with reduced CRIg expression, exacerbate liver injury by allowing sustained inflammation.44 Therefore, therapeutic strategies that promote M2 polarisation or enhance CRIg function could hold promise for treating ALD and reducing its progression to more severe forms, such as fibrosis and cirrhosis